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. 2004 Feb;72(2):1036–1042. doi: 10.1128/IAI.72.2.1036-1042.2004

FIG. 2.

FIG. 2.

S. enterica serovar Typhimurium requires nonsterol intermediates of host sterol biosynthesis. (A) Intracellular growth of S. enterica serovar Typhimurium in RAW 264.7 macrophages treated with various media and supplements. Growth is expressed as the number of bacteria recovered at 20 h relative to the number of bacteria recovered at 2 h. (B) Intracellular growth curve for S. enterica serovar Typhimurium infection in control (▪) and 30 μM lovastatin-treated (▴) RAW 264.7 macrophages. (C) Phagocytosis of fluorescent latex beads in control and 30 μM lovastatin-treated macrophages. The percentages indicate the percentages of bead-containing cells relative to the total number of cells. (D) Intracellular growth of nonopsonized S. enterica serovar Typhimurium in control or 30 μM lovastatin-treated RAW 264.7 macrophages. The data are means ± standard errors of the means for three replicates.