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. 2011 Jun 27;193(7):1275–1288. doi: 10.1083/jcb.201009126

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© 2011 Yamaguchi et al.

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Figure 8. — A model of the function of PI3K signaling in invadopodia formation and cell invasion. p110α that is activated downstream of growth factor receptors produces the signaling lipid PI(3,4,5)P₃ to regulate invadopodia formation and cancer cell invasion. PI(3,4)P₂ that is generated via dephosphorylation of PI(3,4,5)P₃ by synaptojanin-2 (SJ2) may regulate invadopodia formation through the Tks5/N-WASP axis in parallel with PI(3,4,5)P₃. PDK1 and Akt are activated by both PI(3,4,5)P₃ and PI(3,4)P₂ and act as mediators of the PI3K signaling pathway for invadopodia formation.