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. 2011 Jun 27;193(7):1181–1196. doi: 10.1083/jcb.201006114

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© 2011 Qian et al.

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Figure 1. — Genetic screen identifying Cdc42. (A) Candidate deficiency lines interacting with tin³⁴⁶ (susceptibility to pacing-induced heart arrest or fibrillation). (B) Genetic interaction between tinman, Cdc42, and deficiency 7721. Cdc42^+/−;tin^+/− flies show dramatic increase in pacing-induced heart arrest or fibrillation rate compared with Cdc42^+/− or tin^+/− (Chi square analysis: *, P < 0.01). (C) TARGET-mediated overexpression (see Materials and methods) of dominant-negative Cdc42 (Cdc42^N17) in the adult heart results in elevated heart dysfunction (*, P < 0.01). Each bar in B and C represents a single experiment. n, number of flies tested.