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. 2011 Jun 27;193(7):1181–1196. doi: 10.1083/jcb.201006114

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© 2011 Qian et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

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Figure 6. — Overexpression of miR-1 causes arrhythmias in the adult fly heart. (A) M-mode traces illustrate arrhythmic heart contractions with cardiac miR-1 overexpression (tinCΔ4Gal4/UASmiR-1). (B–D) Statistical analysis of heart contraction in miR-1–overexpressing adult hearts. (E) Cardiac qPCR of fly Cdc42 (DmCdc42) and potassium channels slowpoke (slo) with tinCΔ4Gal4/UASmiR-1. Heart-specific overexpression of miR-1 resulted in reduced cardiac expression of Cdc42 and slo. *, P < 0.05.