Table 2.
Effects of candidate of tumor suppressor biomarkers in melanoma progression.
| Biomarker | Biological effect(s) associated with biomarker downregulation | Reference |
|---|---|---|
| BAK | Weak BAK expression in serum of patients with melanoma was associated with lesions presenting “sparse” dermal nests | [48] |
|
| ||
| CIMP (WIF1, TFPI2, RASSF1A, and SOCS1) | Associated with advancing clinical stage of melanoma | [28] |
|
| ||
| KLOTHO | Associated with melanoma cell motility and invasiveness | [49] |
|
| ||
| microRNA-211 | Associated with melanoma cells invasiveness | [50] |
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| ||
| microRNA-29c | Predicted overall survival in patients with lymph node metastases | [27] |