Table 2.
Results of color Doppler imaging in normal volunteers.
| Parameter | Nipradilo1 | Placebo | ||||
|---|---|---|---|---|---|---|
| Before | 2 hrs (P) | 1 week (P) | Before | 2 hrs (P) | 1 week (P) | |
| Ophthalmic artery | ||||||
| PSV (cm/sec) | 35.8 ± 8.4 | 31.8 ± 8.6 (0.0044)* | 34.8 ± 8.6 (0.4769) | 32.3 ± 10.8 | 31.8 ± 8.5 (0.6379) | 31.6 ± 10.1 (0.5303) |
| EDV (cm/sec) | 8.03 ± 2.40 | 7.52 ± 2.55 (0.4236) | 8.76 ± 2.69 (0.0969) | 8.17 ± 3.95 | 7.79 ± 2.13 (0.8753) | 8.30 ± 2.89 (0.9063) |
| Resistance index | 0.776 ± 0.035 | 0.764 ± 0.046 (0.2858) | 0.749 ± 0.033 (0.0329*) | 0.753 ± 0.065 | 0.753 ± 0.037 (0.7836) | 0.738 ± 0.036 (0.3078) |
| Central retinal artery | ||||||
| PSV (cm/sec) | 11.3 ± 3.1 | 11.4 ± 2.4 (0.9999) | 12.0 ± 2.5 (0.1095) | 11.9 ± 2.4 | 12.4 ± 2.2 (0.3739) | 12.6 ± 2.4 (0.1823) |
| EDV (cm/sec) | 4.18 ± 1.06 | 4.28 ± 0.91 (0.5937) | 4.67 ± 0.92 (0.0409*) | 4.53 ± 1.27 | 4.38 ± 1.03 (0.8240) | 4.73 ± 0.94 (0.8589) |
| Resistance index | 0.627 ± 0.038 | 0.622 ± 0.051 (0.4145) | 0.606 ± 0.058 (0.1414) | 0.623 ± 0.052 | 0.646 ± 0.059 (0.2662) | 0.622 ± 0.057 (0.9999) |
| NPCA | ||||||
| PSV (cm/sec) | 8.13 ± 1.85 | 8.36 ± 1.60 (0.4769) | 8.02 ± 1.46 (0.8589) | 9.43 ± 1.69 | 9.79 ± 1.22 (0.4243) | 9.08 ± 0.89 (0.3743) |
| EDV (cm/sec) | 3.43 ± 1.10 | 3.53 ± 0.78 (0.6833) | 3.33 ± 0.85 (0.8588) | 3.73 ± 0.81 | 4.06 ± 0.53 (0.2408) | 3.66 ± 0.57 (0.5746) |
| Resistance index | 0.584 ± 0.059 | 0.579 ± 0.041 (0.4496) | 0.584 ± 0.067 (0.9999) | 0.605 ± 0.051 | 0.582 ± 0.056 (0.2477) | 0.596 ± 0.054 (0.3863) |
| TPCA | ||||||
| PSV (cm/sec) | 10.2 ± 2.8 | 10.0 ± 3.1 (0.7895) | 10.6 ± 2.9 (0.5337) | 11.3 ± 3.0 | 11.0 ± 3.1 (0.7213) | 10.9 ± 2.3 (0.2475) |
| EDV (cm/sec) | 3.95 ± 1.27 | 4.25 ± 1.45 (0.0365)* | 4.36 ± 1.68 (0.4236) | 4.53 ± 1.36 | 4.72 ± 1.74 (0.4496) | 4.44 ± 1.35 (0.2662) |
| Resistance index | 0.614 ± 0.060 | 0.578 ± 0.057 (0.0164)* | 0.600 ± 0.065 (0.2477) | 0.597 ± 0.050 | 0.584 ± 0.043 (0.3739) | 0.592 ± 0.074 (0.9292) |
Values are presented as mean ± standard deviation. PSV: peak systolic velocity, EDV: end-diastolic velocity, NPCA: nasal short posterior ciliary artery, TPCA: temporal short posterior ciliary artery.
Wilcoxon signed-rank sum test.
(P)* < 0.05.