Table 1.
Effects of H2S.
| Cause | Effect |
|---|---|
| Vasodilator | H2S like NO and CO, causes the opening the potassium adenosine triphosphate (KATP) channels [37] |
| Apoptosis modulator | Via the activation of the mitogen-activated protein kinases (MAPK) pathway [41] |
| Protection against oxidative stress | Increases GSH synthesis and recovery of cysteine transport [24, 42, 43]. Scavenging of hydroxyl, oxygen and nitric oxide free radicals and reduces the accumulation of lipid peroxidation [44–46] |
| Neuromodulator | Enhances activity of N-Methyl-D-aspartic acid (NMDA) receptor and activates calcium channels, which regulates synaptic transmission in neurons [4] |