Table 4.
Effects of 2'-FdC Treatment of BALB/c Mice Infected with Influenza/A/Vietnam/1203/2004 H5N1 Virus on Various Lung Parameters at Day 4 Post Virus Exposure
| Treatment | Lung Score ± SDa |
Lung WeightSD ± SDa |
Virus Lung Titers ± SD (Log10/g)a |
|---|---|---|---|
| 0.4% CMC | 0.4 ± 0.22 | 0.17 ± 0.011 | 4.10 ± 1.052 |
| 2'-FDC (60 mg/kg/d) | 0.4 ± 0.25 | 0.14 ± 0.014 | 3.60 ± 1.303 |
| 2'-FDC (30 mg/kg/d) | 0.2 ± 0.27 | 0.13 ± 0.012* | 4.01 ± 0.713 |
| Ribavirin (75 mg/kg/d) | 0.6 ± 0.13 | 0.12 ± 0.014** | 1.42 ± 0.000** |
Values represent the arithmetic the standard deviation.
P<0.05,
P<0.01 vs. 0.4% CMC treatment group by ANOVA and Newman-Keuls pairwise comparison test.