6.
Effects of 2’-FdC On Various Death Parameters for BALB/C Mice Infected with Pandemic Influenza A/CA/04/09 H1N1 Virus
| Treatment | Live/Total | Median Day of Death |
Mean Day of Death ± SD |
Hazard Ratio (95% CI)a |
|---|---|---|---|---|
| PSS Dunn’s posttest | 1/14 | 10.0 | 8.9 ± 1.6 | − |
| 2'-FdC (30 mg/kg/d) | 5/10 | Undefined | 7.8 ± 1.3 | 2.95 (1.06–8.17) |
| 2'-FdC (3 mg/kg/d) | 4/10 | 10.0 | 8.9 ± 1.2 | 2.17 (0.81–5.82) |
| 2'-FdC (0.3 mg/kg/d) | 0/10 | 6.0 | 9.3 ± 2.1 | 0.76 (0.29–1.99) |
| Ribavirin (75 mg/kg/d) | 10/10** | Undefined | >21*** | 47.7 (14.1–162) |
a
Hazards ratios are relative to the PSS control.
***
P<0.001 versus PSS control by Kruskal-Wallis test and Dunn’s posttest for pairwise comparisons.
**
P = 0.0095 versus PSS control by Chi-square analysis and Fisher’s exact test for pairwise comparisons.