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. 2011 Sep 2;124(2):299–310. doi: 10.1093/toxsci/kfr226

FIG. 3.

FIG. 3.

Scd1 activity (desaturation) index (A) in female TCDD (T) or vehicle (V) treated Scd1+/+ and Scd1−/− mice. The desaturation index is the ratio of palmitoleic (16:1n7) or oleic acid (18:1n9) to the precursors palmitic (16:0) or stearic acids (18:0), respectively. Bars represent mean ± SEM, n = 5 biological replicates. *, p < 0.05 for TCDD compared with vehicle within a genotype; **, p < 0.05 for Scd1−/− TCDD compared with Scd1+/+ TCDD; ***, p < 0.05 for Scd1−/− vehicle compared with Scd1+/+ vehicle. Data were analyzed by factorial ANOVA followed by Tukey’s post hoc test. (B) Correlation analysis was performed in Graphpad Prism 5.0a between the hepatic triglyceride (TRG) levels and the 18:1n9/18:0 desaturation index in Scd1+/+ mice gavaged with 30 μg/kg with TCDD or vehicle for 168 h.