TABLE 1.
Total Hepatic Lipid Composition (μmol/g liver) in Scd1+/+ and Scd1−/− Mice 168 h Post 30 μg/kg TCDD Dose
| Lipids | Scd1+/+ Vehicle | Scd1+/+ TCDD | Scd1−/− Vehicle | Scd1−/− TCDD |
| Total FAs | 81.4 ± 10.4 | 153.6 ± 26.7* | 87.6 ± 7.3 | 137.8 ± 11.1* |
| SFA | 40.6 ± 6.5 | 64.6 ± 11.1* | 52.3 ± 5.3 | 68.8 ± 7.1* |
| Palmitic acid (16:0) | 19.9 ± 2.6 | 29.2 ± 3.7* | 19.8 ± 2.6 | 27.8 ± 2.8* |
| Stearic acid (18:0) | 17.0 ± 3.1 | 20.2 ± 2.2*,** | 19.6 ± 2.1 | 27.1 ± 3.2* |
| Arachidic acid (20:0) | 0.064 ± 0.006 | 0.066 ± 0.010 | 0.117 ± 0.076 | 0.093 ± 0.011 |
| Behenic acid (22:0) | 0.269 ± 0.044*** | 0.175 ± 0.017 | 0.425 ± 0.140 | 0.292 ± 0.056 |
| Lignoceric acid (24:0) | 3.33 ± 1.01*** | 14.9 ± 7.3* | 12.4 ± 1.9 | 13.4 ± 1.9 |
| MUFA | 12.7 ± 1.5*** | 36.8 ± 7.8*,** | 5.1 ± 0.5 | 15.8 ± 0.01* |
| Palmitoleic acid (16:1n7) | 1.24 ± 0.26*** | 2.39 ± 0.64*,** | 0.20 ± 0.03 | 0.46 ± 0.08 |
| Oleic acid (18:1n9) | 11.2 ± 1.4*** | 32.9 ± 6.9*,** | 4.68 ± 0.44 | 14.7 ± 1.8* |
| Eicosenoic acid (20:1n9) | 0.10 ± 0.015*** | 0.72 ± 0.22*,** | 0.040 ± 0.008 | 0.27 ± 0.056* |
| Erucic acid (22:1n9) | 0.028 ± 0.005 | 0.056 ± 0.009* | 0.031 ± 0.005 | 0.064 ± 0.009* |
| Nervonic acid (24:1n9) | 0.135 ± 0.043 | 0.802 ± 0.353*,** | 0.189 ± 0.047 | 0.277 ± 0.040 |
| PUFA | 28.1 ± 3.4 | 52.2 ± 10.1* | 30.1 ± 2.4 | 53.2 ± 5.3* |
| Total n3 FAs | 1.30 ± 0.37 | 4.23 ± 1.56* | 1.85 ± 0.49 | 3.70 ± 0.36* |
| Total n6 FAs | 26.7 ± 3.09 | 47.6 ± 8.5* | 28.2 ± 2.0 | 49.2 ± 4.9* |
| Linoleic acid (18:2n6) | 14.8 ± 1.83 | 31.7 ± 5.67* | 16.7 ± 1.65 | 31.7 ± 3.53* |
| Eicosadienoic acid (20:2n6) | 0.31 ± 0.042 | 1.26 ± 0.26* | 0.30 ± 0.040 | 1.20 ± 0.25* |
| Dihomo-γ-linolenic acid (20:3n6) | 0.95 ± 0.10 | 2.60 ± 0.69* | 0.786 ± 0.111 | 2.52 ± 0.37* |
| Arachidonic acid (20:4n6) | 10.6 ± 1.38 | 12.0 ± 2.66 | 10.4 ± 0.88 | 13.7 ± 1.06* |
| Docosapentaenoic acid (22:2n6) | 0.015 ± 0.007 | 0.035 ± 0.012* | 0.018 ± 0.004 | 0.042 ± 0.008* |
| Eicosatetraenoic acid (20:4n3) | 0.033 ± 0.005 | 0.162 ± 0.057* | 0.032 ± 0.006 | 0.153 ± 0.046* |
| α-Linolenic acid (18:3n3) | 0.458 ± 0.101 | 1.36 ± 0.30* | 0.045 ± 0.088 | 1.09 ± 0.25* |
| Timnodonic acid (20:5n3) | 0.614 ± 0.240 | 0.593 ± 0.231 | 0.629 ± 0.234 | 0.694 ± 0.146 |
| Docosapentaenoic acid (22:5n3) | 0.193 ± 0.078 | 2.12 ± 1.04* | 0.743 ± 0.232 | 1.76 ± 0.24* |
Note. Data were analyzed by factorial ANOVA followed by Tukey’s post hoc test, n = 5 biological replicates. *, p < 0.05 for TCDD versus Vehicle within the same genotype; **, p < 0.05 for +/+ TCDD versus −/− TCDD; ***, p < 0.05 for +/+ Vehicle versus −/− Vehicle.