TABLE 4.
PFP-Induced Gene Transcriptional Alterations in Adult Rat Airways
| Symbol | RefSeq | Gene Name | Fold Regulation | p Value |
| Antioxidant and oxidative stress | ||||
| Ctsb | NM_022597 | Cathepsin B | 3.0707 | 0.035618 |
| Cygb | NM_130744 | Cytoglobin | 9.0559 | 0.014945 |
| Duox2 | NM_024141 | Dual oxidase 2 | 70.0018 | 0.012265 |
| Epx | XM_220834 | Eosinophil peroxidase | 7.6222 | 0.017935 |
| Ephx2 | NM_022936 | Epoxide hydrolase 2, cytoplasmic | −36.9837 | 0.019421 |
| Gpx1 | NM_030826 | Glutathione peroxidase 1 | 4.8268 | 0.036295 |
| Gpx2 | NM_183403 | Glutathione peroxidase 2 | 6.9735 | 0.024608 |
| Gpx6 | NM_147165 | Glutathione peroxidase 6 | −191.402 | 0.044251 |
| Gpx8 | XM_215486 | Glutathione peroxidase 8 | 4.2725 | 0.027142 |
| Gsr | NM_053906 | Glutathione reductase | −13.2797 | 0.028066 |
| Gstm1 | NM_017014 | Glutathione S-transferase mu 1 | −11.0965 | 0.001293 |
| Gstm3 | NM_031154 | Glutathione S-transferase mu 3 | −27.0246 | 0.013771 |
| Hmox1 | NM_012580 | Heme oxygenase (decycling) 1 | −30.9446 | 0.000458 |
| Hmox2 | NM_024387 | Heme oxygenase (decycling) 2 | −24.3281 | 0.028834 |
| Idh1 | NM_031510 | Isocitrate dehydrogenase 1 (NADP+), soluble | 5.6885 | 0.015345 |
| Nox4 | NM_053524 | NADPH oxidase 4 | 3.5661 | 0.038669 |
| Por | NM_031576 | P450 (cytochrome) oxidoreductase | −7.477 | 0.009219 |
| Prdx1 | NM_057114 | Peroxiredoxin 1 | 3.882 | 0.013839 |
| Prdx3 | NM_022540 | Peroxiredoxin 3 | 3.0562 | 0.048917 |
| Prnp | NM_012631 | Prion protein | 7.9351 | 0.031433 |
| Ptgs2 | NM_017232 | Prostaglandin-endoperoxide synthase 2 | 49.6539 | 0.023834 |
| Slc41a3 | NM_001037492 | Solute carrier family 41, member 3 | 5.2298 | 0.047979 |
| Sod1 | NM_017050 | Superoxide dismutase 1, soluble | 3.6862 | 0.031726 |
| Sod2 | NM_017051 | Superoxide dismutase 2, mitochondrial | 3.5975 | 0.041264 |
| Xpa | XM_216403 | Xeroderma pigmentosum, complementation group A | 4.4286 | 0.010963 |
| Heat shock proteins | ||||
| Hspa4 | NM_153629 | Heat shock protein 4 | 1.8433 | 0.016881 |
| Hspa1a | NM_031971 | Heat shock 70kD protein 1A | −67.6156 | 0.014389 |
| Inflammation | ||||
| Ccl21b | NM_001008513 | Chemokine (C-C motif) ligand 21b (serine) | −11.0321 | 0.016656 |
| Ccl3 | NM_013025 | Chemokine (C-C motif) ligand 3 | −7.5797 | 0.046574 |
| Il18 | NM_019165 | Interleukin 18 | 3.3456 | 0.002379 |
| Lta | NM_080769 | Lymphotoxin alpha (TNF superfamily, member 1) | −12.2652 | 0.010425 |
| Nfkb1 | XM_342346 | Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | −33.0979 | 0.01622 |
| Necrosis and apoptosis | ||||
| Anxa5 | NM_013132 | Annexin A5 | −41.4567 | 0.012066 |
| Bax | NM_017059 | Bcl2-associated X protein | −33.2827 | 0.010506 |
| Bcl2l1 | NM_031535 | Bcl2-like 1 | −40.9219 | 0.025367 |
| Chek2 | NM_053677 | CHK2 checkpoint homolog (Schizosaccharomyces. pombe) | −15.4004 | 0.013171 |
| Ercc2 | XM_218424 | Excision repair cross-complementing rodent repair deficiency, complementation group 2 | −27.6876 | 0.010995 |
| Ercc4 | XM_222534 | Excision repair cross-complementing rodent repair deficiency, complementation group 4 | −14.0267 | 0.026123 |
| Rad23a | NM_001013190 | RAD23 homolog A (Saccharomyces. cerevisiae) | −7.4534 | 0.03773 |
| Tradd | XM_341671 | TNFRSF1A-associated via death domain | −26.2046 | 0.030071 |
| Tnfrsf1a | NM_013091 | Tumor necrosis factor receptor superfamily, member 1a | −53.5655 | 0.046099 |
| Ugt1a6 | NM_057105 | UDP glucuronosyltransferase 1 family, polypeptide A6 | −15.3658 | 0.010749 |
| Ung | NM_001013124 | Uracil-DNA glycosylase | −24.0967 | 0.030458 |
| Xrcc1 | NM_053435 | X-ray repair complementing defective repair in Chinese hamster cells 1 | −29.3218 | 0.005521 |
| Proliferation and carcinogenesis | ||||
| Ccnd1 | NM_171992 | Cyclin D1 | −3.9014 | 0.008242 |
| Egr1 | NM_012551 | Early growth response 1 | −127.066 | 0.002162 |
| Cdkn1a | NM_080782 | Cyclin-dependent kinase inhibitor 1A (p21, Cip1) | −20.8561 | 0.016276 |
| Igfbp6 | NM_013104 | Insulin-like growth factor binding protein 6 | −43.9 | 0.019266 |
| Tp53 | NM_030989 | Tumor protein p53 | −22.9176 | 0.026688 |
| Xenobiotic metabolism | ||||
| Cyp2a3a | NM_012542 | Cytochrome P450, family 2, subfamily A, polypeptide 3a | −10.7957 | 0.001177 |
| Cyp4a3 | NM_175760 | Cytochrome P450, family 4, subfamily a, polypeptide 3 | −9.4802 | 0.005024 |
| Fmo2 | NM_144737 | Flavin containing monooxygenase 2 | 5.8038 | 0.026673 |
| Fmo5 | NM_144739 | Flavin containing monooxygenase 5 | −9.1731 | 0.023699 |