TABLE 3.

Immune Modulation by I3C and IO Is Not Entirely AhR-Mediated in BMDCs^a—Immunophenotype of Unstimulated Cells

Surface marker	AhR+/+			AhR−/−
	DMSO	I3C	IO	DMSO	I3C	IO
CD11c	3391 ± 142	2603 ± 326*	2219 ± 312*	4611 ± 548	4822 ± 107	3992 ± 280
MHC2	2833 ± 81	8056 ± 400*	6432 ± 255*	1970 ± 100	2912 ± 125*	2067 ± 100
CD86	1299 ± 15	1493 ± 3*	1270 ± 10	1279 ± 5	950 ± 27*	1180 ± 31*
CD80	1176 ± 23	1901 ± 8*	1412 ± 8*	839 ± 14	1129 ± 14*	822 ± 13
CD54	548 ± 7	507 ± 11*	435 ± 6*	649 ± 6	630 ± 12	633 ± 10
CD40	334 ± 72	290 ± 11*	291 ± 5*	409 ± 18	308 ± 16*	358 ± 6*

^aAhR^+/+ and AhR^−/− BMDCs were grown in the presence of vehicle, 50μM I3C or 1μM IO and subsequently immunophenotyped prior to LPS stimulation. Mean fluorescence intensity values are shown as mean ± standard error. Data are representative of two independent experiments with n = 3.

*Significance of p ≤ 0.05 compared with DMSO control of respective cell type.