Table 1. Clinicopathological features in relation to EGFR mutations in patients with lung cancer.
Variables | Category | n | EGFR mutation (%) | Exon 19 deletion | Exon 21 L858R | |
---|---|---|---|---|---|---|
Gender | Male | 302 | 62a | 20.5% | 34 | 29 |
Female | 167 | 76 | 45.5% | 28 | 48 | |
Histology | Adenocarcinoma | 322 | 136a | 42.2% | 62 | 75 |
Squamous cell ca. | 102 | 0 | 0.0% | |||
Large cell ca. | 27 | 1 | 3.7% | 1 | ||
Small cell ca. | 13 | 0 | 0.0% | |||
Pleomorphic ca. | 2 | 1 | 50.0% | 1 | ||
Adenosquamous ca. | 1 | 0 | 0.0% | |||
Carcinoid tumour | 1 | 0 | 0.0% | |||
Spindle cell ca. | 1 | 0 | 0.0% | |||
Smoking | Never | 138 | 74a | 53.6% | 29 | 46 |
Formerb | 114 | 31 | 27.2% | 18 | 13 | |
Current | 217 | 33 | 15.2% | 15 | 18 | |
Total | 469 | 138a | 29.4% | 62 | 77 |
One case had mutations in both exons 19 and 21.
Former smokers are defined persons who stopped smoking more than 3 years previously.