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. 2006 Mar 21;94(6):896–903. doi: 10.1038/sj.bjc.6603040

Table 1. Clinicopathological features in relation to EGFR mutations in patients with lung cancer.

Variables Category n EGFR mutation (%) Exon 19 deletion Exon 21 L858R
Gender Male 302 62a 20.5% 34 29
  Female 167 76 45.5% 28 48
             
Histology Adenocarcinoma 322 136a 42.2% 62 75
  Squamous cell ca. 102 0 0.0%    
  Large cell ca. 27 1 3.7%   1
  Small cell ca. 13 0 0.0%    
  Pleomorphic ca. 2 1 50.0%   1
  Adenosquamous ca. 1 0 0.0%    
  Carcinoid tumour 1 0 0.0%    
  Spindle cell ca. 1 0 0.0%    
             
Smoking Never 138 74a 53.6% 29 46
  Formerb 114 31 27.2% 18 13
  Current 217 33 15.2% 15 18
             
  Total 469 138a 29.4% 62 77
a

One case had mutations in both exons 19 and 21.

b

Former smokers are defined persons who stopped smoking more than 3 years previously.