Table 2.
Outcomes in infants with simple or complex gastroschisis*. Figures are percentages* (numbers) of infants
| Simple (n=251) | Complex (n=31) | Relative risk (95% CI) | P value | |
|---|---|---|---|---|
| Liver disease associated with intestinal failure | 4 (11) | 23 (7) | 5.13 (2.15 to 12.3) | 0.001 |
| Required unplanned reoperation | 10 (24) | 42 (13) | 4.39 (2.50 to 7.70) | <0.001 |
| Unplanned reoperations by indication for surgery†: | ||||
| Ischaemic bowel | 1 (3) | 10 (3) | 8.10 (1.71 to 38.4) | 0.02 |
| Necrotising enterocolitis | 0.4 (1) | 3 (1) | 8.09 (0.52 to 126.2) | 0.2 |
| Adhesional small bowel obstruction | 4 (10) | 13 (4) | 3.23 (1.08 to 9.71) | 0.06 |
| Infective complication | 1 (2) | 0 (0) | 0 (0 to 43.6) | 1.0 |
| Anastomotic stricture | 1 (2) | 10 (3) | 12.1 (2.11 to 69.9) | 0.01 |
| Complications related to stoma | 0 (0) | 3 (1) | ∞ (0.21 to ∞) | 0.1 |
| Silo related | 1 (3) | 0 (0) | 0 (0 to 20.0) | 1.0 |
| Bowel lengthening procedure | 0 (0) | 3 (1) | ∞ (0.21 to ∞) | 0.1 |
| Liver transplantation | 0 (0) | 3 (1) | ∞ (0.21 to ∞) | 0.1 |
| Other unplanned laparotomy | 0.5 (1) | 6 (2) | 16.2 (1.51 to 173.5) | 0.03 |
| Other unplanned operation | 3 (7) | 10 (3) | 3.47 (0.95 to 12.7) | 0.09 |
| Parenteral nutrition >28 days‡ | 41 (102) | 81 (25) | 1.96 (1.56 to 2.46) | <0.001 |
| Days to discharge§: | ||||
| <30 | 37 (91) | 7 (2) | — | <0.001 |
| 31-59 | 35 (85) | 27 (8) | ||
| ≥60 | 28 (68) | 67 (20) | ||
*In seven cases there was insufficient information to enable classification into complex or simple; these cases have been excluded.
†Some infants required more than one unplanned reoperation.
‡Includes two infants who had not attained full enteral feeding at one year. Median time (days) to full enteral feeding (excluding infants who died in neonatal period) was 24 (interquartile range 17-39, range 3->365) in infants with simple gastroschisis and 47 (30-83, range 15-297) in infants with complex gastroschisis (P<0.001).
§Excludes all infants who died.