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Glutathione abrogates curcumin-mediated inhibition of NF-κB but has no effect on DBA-, DBM-, or DBP-mediated inhibition of NF-κB. KBM-5 cells were incubated with 10 mM GSH for 2 h and treated with 100 μM DBP, 50 μM DBA, 200 μM DBM and 50 μM curcumin for 4 h. Then the cells were activated with 0.1 nM TNF-α for 30 min and subjected to EMSA assay for NF-κB activation. Cell viability (C.V.) was determined by the trypan blue exclusion assay.
