TABLE I.
Samples | Radiochemical species | Condition
|
|
---|---|---|---|
Baseline (%) | Depletion (%) | ||
Brain | [11C]MNPA | 89.6 ± 0.9 | 92.0 ± 1.2 |
Radiometabolites | 10.4 ± 1.7 | 8.0 ± 1.8 | |
Plasma | [11C]MNPA | 28.6 ± 21.6 | 38.7 ± 18.2 |
Radiometabolites | 71.4 ± 16.4 | 61.3 ± 19.3 |
Rats were euthanized 30 min after injection of [11C]MNPA, and radioactivity was extracted from brain and plasma. Values are average ± SD of radioHPLC analyses (n = 4 in each condition).