Table 3.
Endogenous glucose production and tissue-specific glucose uptake during eugly-caemic–hyperinsulinaemic clamp during normal and high sodium intake
| Variable | Normal sodium |
High sodium |
||
|---|---|---|---|---|
| Wild-type n=3 |
As−/− n=6 |
Wild-type n=4 |
As−/− n=10 |
|
| EndoRa (mg kg−1 min−1) | NA | NA | 15.4±2.0 | 15.1 ±0.9 |
| Tissue Rg (µg min−1[mg tissue]−1) | ||||
| Gastrocnemius | 14.6±2.1 | 9.4±2.2 | 16.5±4.8 | 12.8±2.2 |
| Vastus lateralis | 14.0±2.3 | 8.7±2.1 | 14.3±2.2 | 10.9±1.9 |
| Soleus | 79.8±19.7 | 54.4±15.2 | 85.3±24.2 | 46.0±8.4 |
| Diaphragm | 133.7±43.8 | 152.9±15.0 | 107.3±20.0 | 80.9±15.3 |
| Heart | 394.1±45.3 | 349.5±40.2 | 239.3±68.7 | 206.2±29.9 |
| Adipose | 3.35±1.0 | 9.06±1.9* | 6.3±1.8 | 5.9±1.0 |
| Brain | 60.6±8.7 | 49.1±3.0 | 53.7±11.9 | 38.6±4.8 |
Data are expressed as mean± SEM
EndoR was not assessed during normal sodium
EndoRa, endogenous glucose production;Rg, glucose uptake
*
p<0.05 vs wild-type