TABLE 2.
Distribution Volume of 11C-NOP-1A in Monkey Brain
| Organ |
VT (mL cm−3)
|
VS (mL cm−3), baseline – blocked | VS/VT (%) | |||
|---|---|---|---|---|---|---|
| Baseline
|
Blocked
|
|||||
| Mean | SD | Mean | SD | |||
| Prefrontal cortex | 18.1 | 0.9 | 6.6 | 2.3 | 11.6 | 64 |
|
| ||||||
| Basal frontal cortex | 16.6 | 1.0 | 6.1 | 1.7 | 10.5 | 63 |
|
| ||||||
| Parietal cortex | 19.3 | 2.5 | 6.8 | 2.2 | 12.5 | 65 |
|
| ||||||
| Occipital cortex | 20.4 | 2.2 | 6.6 | 1.8 | 13.7 | 67 |
|
| ||||||
| Insula | 19.8 | 2.2 | 7.5 | 1.9 | 12.3 | 62 |
|
| ||||||
| Lateral temporal cortex | 21.3 | 1.0 | 7.2 | 2.0 | 14.2 | 66 |
|
| ||||||
| Medial temporal cortex | 16.5 | 1.3 | 6.6 | 1.2 | 9.9 | 60 |
|
| ||||||
| Amygdala | 21.0 | 3.7 | 7.3 | 1.8 | 13.7 | 65 |
|
| ||||||
| Hippocampus | 18.1 | 3.0 | 7.1 | 1.5 | 11.0 | 61 |
|
| ||||||
| Anterior cingulate | 17.7 | 1.4 | 7.4 | 1.8 | 10.3 | 58 |
|
| ||||||
| Posterior cingulate | 17.6 | 1.4 | 7.2 | 1.8 | 10.4 | 59 |
|
| ||||||
| Caudate | 15.3 | 0.2 | 7.2 | 1.9 | 8.1 | 53 |
|
| ||||||
| Putamen | 16.0 | 1.3 | 7.6 | 1.9 | 8.5 | 53 |
|
| ||||||
| Thalamus | 16.2 | 0.7 | 8.0 | 2.0 | 8.2 | 51 |
|
| ||||||
| Hypothalamus | 12.6 | 1.2 | 7.4 | 1.8 | 5.2 | 41 |
|
| ||||||
| Cerebellum | 12.9 | 1.1 | 6.7 | 1.4 | 6.2 | 48 |