Table 2. Allelic frequencies of non-synonymous mutations in the ZIC2 gene in patients with schizophrenia and control subjects.
| Control | Schizophrenia | Polyphen (PSIC)1 | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Polymorphism | Genotype count | MAF2 | Genotype count | MAF | |||||
| Ala95Thr (283G>A) | G/G | G/A | A/A | 0 | G/G | G/A | A/A | 0.041 | Benign (0.897) |
| 1,036 | 0 | 0 | 1,226 | 1 | 0 | ||||
| Ins239His | del/del | del/ins | ins/ins | 8.95 | del/del | del/ins | ins/ins | 8.77 | |
| 865 | 173 | 7 | 1,025 | 198 | 9 | ||||
| Arg409Pro (1,226G>C) | G/G | G/C | C/C | 0 | G/G | G/C | C/C | 0.04 | Probably damaging (2.745) |
| 1,058 | 0 | 0 | 1,238 | 1 | 0 | ||||
| Ser444Arg (1,332C>A) | C/C | C/A | A/A | 0.284 | C/C | C/A | A/A | 0.363 | Possibly damaging (1.541) |
| 1,051 | 6 | 0 | 1,230 | 9 | 0 | ||||
1Polyphen is a computer algorithm used to predict the effects of non-synonymous single-nucleotide polymorphisms (SNPs) on protein structure and function 30. PSIC, difference in position-specific independent counts.
2MAF, minor allele frequency