Table 1. After the divergence of human and chimpanzee lineages, eleven fixed amino-acid changes occurred on the human lineage, whereas six occurred on the chimpanzee lineage.
| Ka/Ks > 1 | Position | Ancestral residue | Replacement in Chimpanzee | Replacement in Human | Neutral/Radical | Region |
|---|---|---|---|---|---|---|
| Region-1 | ||||||
| 175 | R | H | Neutral (0) | Nuclear matrix targeting signal | ||
| 180 | P | A | Radical (-1) | |||
| 186 | W | C | Radical (-2) | |||
| Region-2 | ||||||
| 233 | P | S | Radical (-1) | RD1 | ||
| 276 | R | W | Radical (-3) | |||
| 289 | T | S | Radical (1) | |||
| 287 | V | A | Neutral (0) | |||
| Region-3 | ||||||
| 458 | E | D | Radical (2) | Uncharacterized | ||
| 496 | Q | E | Radical (2) | |||
| 511 | A | T | Neutral (0) | |||
| 534 | A | T | Neutral (0) | |||
| Region-4 | ||||||
| 645 | T | A | Neutral (0) | Uncharacterized | ||
| 660 | T | M | Radical (-1) | |||
| Region-5 | ||||||
| 852 | R | Q | Radical (1) | RD3 | ||
| 854 | W | C | Radical (-2) | |||
| Region-6 | ||||||
| 910 | T | S | Radical (1) | RD3 | ||
| Region-7 | ||||||
| 1022 | A | T | Neutral (0) | JmjC | ||
The table shows the putative ancestral amino acid residues and the type of replacement occurred in each lineage since their divergence. The 6th column depicts the putative physicochemical impact of each replacement on protein structure/function. The numbers within bracket are the log odds scores associated with changing the amino acids. Positive numbers imply a preferred change, zero implies a neutral change, and negative numbers imply an un-preferred change.