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. 2011 Oct 19;1:123. doi: 10.1038/srep00123

Figure 5. Effects of HFD on chemerin-deficient mice and GSIS in chemerin-transgenic mice.

Figure 5

(a) Body weights of chemerin (+/+) and (−/−) mice after HFD. Body weights were determined 6 weeks after high-fat diet feeding from 8 weeks of age. (n = 5-8/genotype). (b) Intraperitoneal glucose tolerance test after 8 weeks of HFD in (+/+) and (−/−) mice. (n = 5/genotype). (c) Serum insulin levels after glucose administration following HFD in (+/+) and (−/−) mice. (n = 5/genotype). (d) Characterization of SAP promoter-driven chemerin transgenic mice. Serum (5 μL each) from Tg1, Tg2, wild-type, and chemerin (−/−) mice was subjected to immunoblotting analysis for chemerin. (e) Quantification of serum chemerin concentrations in chemerin transgenic mice. (f) Intraperitoneal glucose tolerance test in 12-week-old chemerin transgenic and wild-type mice. (n = 5/genotype). (g) Serum insulin levels after glucose administration in chemerin transgenic and wild-type mice. (n = 5/genotype).