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. 2011 Nov 7;1:144. doi: 10.1038/srep00144

Figure 5. Revealing novel features of TRAIL signaling using modeling strategy and response rules.

Figure 5

Model simulations compared with experiments. For p38, (A) M0, the initial model, (B) M1 with the addition of a rapid bypass, and (C) M2 with the addition of a missing link between RIP1 and p38 pathway. For JNK (D) M2, (E) M3 with intermediates to introduce delay in activation, (F) M4 with a missing link for the activation of JNK in FADD and caspase-8 KDs, and (G) M5 a missing link between p62 and JNK pathway to show enhancement through SFR in TRAF2 KD.