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Effect of the mutations of various unique aromatic amino acids in the hMC2R on ACTH binding affinity and receptor activity. Panel A shows the ACTH binding affinity to these mutant receptors. Panel B shows the ability of ACTH to stimulate cAMP production upon binding to the mutant receptors. (Panels A and B) (n = 3; see Tables 3 for actual Ki and EC50 values).
