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. 2011 Nov 15;22(22):4362–4372. doi: 10.1091/mbc.E11-04-0283

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© 2011 O'Leary et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

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FIGURE 10: — Pcdh-γB2 VCD is necessary for trafficking of Pcdh-γB2. Full-length γB2-YFP colocalized with LAMP-2 (A) and coclustered with RFP-LC3 (B) as shown previously. Constant-domain-deleted Pcdh-γB2 (γB2Δconst-GFP) also colocalized with LAMP-2 and RFP-LC3. Truncation of most of the VCD (γB2Δct190-GFP) caused the molecule to no longer colocalize with LAMP-2 and RFP-LC3 (A and B, bottom). (C) γB2-YFP and γB2Δconst-GFP both were associated with tubules and multivesicular organelles (arrowheads), whereas γB2Δct190-GFP was associated with disorganized membrane whorls or stacks. (D) Manually adjusted clustal alignment of VCD segments from Pcdh-γAs and Pcdh-γBs. The critical 26–amino acid segment in Pcdh-γA3 is boxed. Bar, 10 μm in A and B and 500 nm in C.