TABLE 1:

PERK facilitates expression of a large number of UPR target genes.

		Fold change (treated/untreated)a
Dependence	Total	>1.0	≥2.0	<1.0	≤0.5
WT	9645b	7324	4737	2321	797
PERK-dependent	4948c	4599	3523	349	190

^aExpression profile summary of gene transcripts, as defined by probe set, that were significantly changed after treatment with tunicamycin (1 mg/kg). The number of induced genes are shown for both the >1.0-fold and ≥2.0-fold thresholds. The repressed genes are also shown for the <1.0- and <0.5-fold thresholds.

^bThe total number of transcripts significantly changed (p ≤ 0.05) by ER stress.

^cThe number of PERK-dependent transcripts that were significantly changed by ER stress.