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Temporal changes in dyspnea score (F, H-J classification) in subpopulations. A) Full analysis set (FAS; all patients), B) Subgroup A [%VC ≥ 70 and SpO2 during 6MET < 90], and C) Subgroup B [PaO2 ≥ 70 and SpO2 during 6MET < 90]. Data are shown as mean ± SE. High-dose (solid line); low dose (dashed line); placebo (dashed line in bold). The mean changes from baseline to week 52 were compared between high or low-dose and placebo groups with ANCOVA.
