Table 2.
Decline in VC and %VC at week 52 in subpopulations characterized by baseline PaO2 at rest and the lowest SpO2
| Item | Category 1 SpO2 |
Category 2 PaO2 |
High-dose Group | Low-dose Group | Placebo Group | P-value | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| LS mean (n) | SE | LS mean (n) | SE | LS mean (n) | SE | H vs P | L vs P | H+L vs P | |||
| Change in VC |
6MWT SpO2≥90 |
PaO2≥70 Torr | -0.115 (43) | 0.032 | -0.060 (22) | 0.045 | -0.137 (36) | 0.035 | 0.6423 | 0.1766 | 0.2667 |
| PaO2<70 Torr | - (1) | - | - (0) | - | - (5) | - | - | - | - | ||
| 6MWT SpO2<90 |
PaO2≥70 Torr | -0.115 (42) | 0.043 | -0.087 (28) | 0.053 | -0.199 (56) | 0.038 | 0.1509 | 0.0881 | 0.0585 | |
| PaO2<70 Torr | -0.014 (15) | 0.067 | -0.102 (4) | 0.129 | -0.135 (6) | 0.105 | 0.34560 | 0.8456 | 0.5556 | ||
| Change in %VC |
6MWT SpO2≥90 |
PaO2≥70 Torr | -3.486 (43) | 1.013 | -2.329 (22) | 1.412 | -4.544 (36) | 1.107 | 0.4833 | 0.2200 | 0.2484 |
| PaO2<70 Torr | - (1) | - | - (0) | - | - (5) | - | - | - | - | ||
| 6MWT SpO2<90 |
PaO2≥70 Torr | -3.755 (42) | 1.379 | -2.629 (28) | 1.698 | -6.124 (5) | 1.199 | 0.1975 | 0.0965 | 0.0744 | |
| PaO2<70 Torr | -0.204 (15) | 2.040 | -3.038 (4) | 3.951 | -3.964 (6) | 3.229 | 0.3364 | 0.8578 | 0.5568 | ||
(-; not calculated.)