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. 2011 Nov 15;6(11):e27445. doi: 10.1371/journal.pone.0027445

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Kilimnik et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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A: Mean relative frequencies of islet sizes and cellular compositions (B: alpha-cell fraction, C: beta-cell fraction, and D: delta-cell fraction) depending on islet size in non-diabetic (gray; 8903 islets with n = 14) and T2D (color; 7929 islets with n = 12) subjects (mean ± SEM). The numbers in parentheses represent effective islet diameters (µm) corresponding to the given logarithmic dimensionless islet areas. Student's t-test compared the results between non-diabetic and T2D subjects at each size bin with *P<0.05, **P<0.001, and ***P<0.0001.