Table 2.
Top Canonical Pathways from IPA for probes showing differential methylation across gestation
| First v Second trimester | p-value | # differentially methylated genes/# genes in the pathway |
|---|---|---|
| Communication between Innate and Adaptive Immune Cells | 6.39E-05 | 6/109 |
| Role of Cytokines in Mediating Communication between Immune Cells | 1.53E-03 | 4/56 |
| Altered T Cell and B Cell Signaling in Rheumatoid Arthritis | 6E-03 | 4/92 |
| Calcium Signaling | 6.81E-03 | 6/204 |
| Crosstalk between Dendritic Cells and Natural Killer Cells | 1.04E-02 | 4/97 |
| Second v Third trimester | p-value | # differentially methylated genes/# genes in the pathway |
| Systemic Lupus Erythematosus Signaling | 4.72E-03 | 5/166 |
| Crosstalk between Dendritic Cells and Natural Killer Cells | 8.2E-03 | 4/97 |
| Role of NFAT in Regulation of the Immune Response | 2.05E-02 | 5/199 |
| Agrin Interactions at Neuromuscular Junction | 2.35E-02 | 3/69 |
| Wnt/β-catenin Signaling | 2.51E-02 | 5/172 |
| First v Third trimester | p-value | # differentially methylated genes/# genes in the pathway |
| Communication between Innate and Adaptive Immune Cells | 1.69E-07 | 17/109 |
| Systemic Lupus Erythematosus Signaling | 1.9E-06 | 21/166 |
| Role of Cytokines in Mediating Communication between Immune Cells | 1.43E-05 | 12/56 |
| Altered T Cell and B Cell Signaling in Rheumatoid Arthritis | 1.79E-04 | 13/92 |
| Crosstalk between Dendritic Cells and Natural Killer Cells | 2.61E-04 | 14/97 |