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. 2011 Nov 15;6(11):e27726. doi: 10.1371/journal.pone.0027726

Figure 5. MLN4924 induces RA sensitization by inducing apoptosis.

Figure 5

Cells were treated with DMSO control, RA (1.5 µM), MLN4924 (0.1 µM for HL-60, 1.0 µM for KG-1) alone or in combination for 24 hrs (HL-60) or 36 hrs (KG-1), followed by FACS analysis for apoptotic sub-G1 population. *, p<0.05; **, p<0.01; ***, p<0.0001, compared to control (A). Cells were treated with indicated drugs at concentrations described above for 24 hrs, followed by DNA fragmentation assay (B) or immunoblotting using indicated antibodies (C).