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. 2011 Nov 15;6(11):e27644. doi: 10.1371/journal.pone.0027644

Figure 3. Administration of R037 inhibits the secretion of inflammatory cytokines.

Figure 3

Lymphocytes were isolated by draining lymph nodes (dLN) and spleens of C57BL/6 mice on day 11 after immunization and restimulating with MOG35–55 for 72 h. IL-17, IFN-γ and IL-10 in the culture supernatants were assayed by ELISA. Decreased IL-17 production by both dLN cells and splenocytes and decreased IFN-γ by splenocytes were observed in the R037-treated group. Data are shown as mean + SEM from a representative of three independent experiments for 6 mice in the R037-treated and 8 in the control groups. **p≤0.01; *p≤0.05.