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. Author manuscript; available in PMC: 2012 Nov 1.

Published in final edited form as: Nucl Med Biol. 2011 Aug 9;38(8):1183–1192. doi: 10.1016/j.nucmedbio.2011.05.005

Table I.

Binding Affinity at Nicotinic α4β2 Receptors

Drug	K_i^a, nM
Nicotine	2.83
Nifene	0.50
Nifrolidine	0.80
Nifzetidine	0.67

^a

Binding assay with ³H-cytisine in rat brain homogenates using reported methods (Pabreza et al., 1991);

^b

Ki calculated from IC₅₀ using Cheng-Prusoff equation (1973) and K_d = 0.59 nM for ³H-cytisine.