Fig. 3.
Bmp signaling in Tbx20 CKO embryos. (A–H) Bmp2 expression is significantly downregulated in the AVC myocardium of Tbx20 CKO mutants at E9.0–9.5 (arrows). C/D and G/H are sagittal sections for A/B and E/F in the heart, respectively. (I–L) Bmp4 is specifically expressed in the OFT in the early heart tube (arrow in I). While Bmp4 expression is unchanged in the OFT (arrow in J), it is ectopically expressed at very low level in the AVC of mutant hearts (arrows in K,L). Bmp7 (M,N) and Bmp10 (O,P) expression are unaffected in the mutants. Arrows indicate the AVC region. LV, left ventricle; LA, left atrium.