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. Author manuscript; available in PMC: 2012 Dec 1.
Published in final edited form as: J Neurochem. 2011 Nov 1;119(5):1074–1085. doi: 10.1111/j.1471-4159.2011.07513.x

Figure 2. ECE-2 WT and KO responses to repeated daily morphine injections.

Figure 2

A. Both WT and ECE-2 KO animals developed tolerance to daily morphine administration on the hot-plate; however, tolerance appeared more rapidly in KO mice. By day 6, no genotype differences were evident. B. Development of tolerance to daily injections of morphine on tail-flick was again significantly slower in WT than KO animals. By day 6, no genotype differences were apparent. MPE, maximum possible effect. N=9 mice/genotype. *p<0.05, WT versus KO mice; #p<0.05, WT response to morphine compared to WT baseline; &p<0.05, KO response to morphine compared to KO baseline.