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Targeting B-cell activation. The B-cell receptor signaling pathway is initiated through phosphorylation of co-receptors Igα (CD79a) and Igβ (CD79b), recruiting the tyrosine kinase SYK. In turn, SYK phosphorylates several downstream kinases including BTK and PI3Kδ. BAFF receptor signaling involves cross-talk with BCR and also results in activation of NFκB. Targeted inhibitors used in clinical trials are shown.
