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. Author manuscript; available in PMC: 2011 Nov 16.
Published in final edited form as: Nat Genet. 2010 May 2;42(6):520–524. doi: 10.1038/ng.562

Figure 1. Loci for susceptibility to PDB detected by genome wide association study.

Figure 1

Manhattan plot of association test results from the discovery cohort showing chromosomal positions of the 294,633 SNPs passing quality control plotted against genomic-control adjusted −log10​ P. Association with Paget’s disease was tested using stratified Cochran-Mantel-Haenszel test. The red horizontal line indicates the threshold for genome wide significance (P < 1.7 × 10−7).