Table 4.

Risk of UGIB and perforation associated with aspirin use according to location, type of lesion and aspirin formulation

		Adjusted* RR (95% CI)
		All cases	UGIB	Perforation
All sites	Plain	1.9 (1.6-2.3)	2.0 (1.6-2.4)	1.6 (1.1-2.5)
	Coated	2.3 (1.6-3.2)	2.2 (1.5-3.2)	2.4 (1.1-5.0)
Gastric	Plain	2.0 (1.5-2.5)	2.0 (1.6-2.6)	- $
	Coated	2.2 (1.4-3.6)	2.3 (1.4-3.8)
Duodenal	Plain	1.6 (1.3-2.1)	1.5 (1.2-2.0)	1.8 (1.1-2.8)
	Coated	2.2 (1.4-3.4)	1.9 (1.1-3.2)	2.9# (1.4-6.1)

^* Adjusted for sex, age, calendar year, antecedents of gastrointestinal disorders, smoking status, alcohol consumption and use of NSAIDs, anticoagulants, steroids, SSRIs and paracetamol $ Only 3 cases of gastric perforation exposed to plain aspirin and none to coated aspirin # Based on 9 exposed cases and 142 controls