Table 3.
Association of Lower Urinary Tract Symptoms Severity with Erectile Dysfunction by Age, Health Professionals Follow-up Study
| Age <65 | Age >65 | |||||
|---|---|---|---|---|---|---|
| # Cases | RR (95%CI)* | RR (95%CI)** | # Cases | RR (95%CI)* | RR (95%CI)** | |
| Incident ED 1995 or later† | ||||||
| AUA Symptom Score§ | ||||||
| No to Low LUTS: 0–7 | 1,145 | 1.0 (ref) | 1.0 (ref) | 1,594 | 1.0 (ref) | 1.0 (ref) |
| Low-Moderate LUTS: 8–14 | 187 | 1.31 (1.14–1.50) | 1.28 (1.11–1.46) | 573 | 1.19 (1.11–1.27) | 1.16 (1.08–1.24) |
| High-Moderate LUTS: 15–19 | 50 | 1.85 (1.46–2.34) | 1.75 (1.39–2.22) | 121 | 1.22 (1.07–1.39) | 1.24 (1.09–1.42) |
| Severe LUTS: 20–35 | 31 | 2.39 (1.80–3.18) | 2.25 (1.68–3.00) | 63 | 1.25 (1.05–1.49) | 1.18 (0.99–1.41) |
| p trend | < 0.0001 | < 0.0001 | < 0.0001 | < 0.0001 | ||
| Surgery for BPH | 17 | 1.30 (0.85–1.99) | 1.33 (0.87–2.05) | 172 | 1.13 (1.01–1.27) | 1.13 (1.01–1.26) |
| p for interaction = 0.03 | ||||||
|
| ||||||
| Incident ED in the last three months‡ | ||||||
| AUA Symptom Score§ | ||||||
| No to Low LUTS: 0–7 | 262 | 1.0 (ref) | 1.0 (ref) | 311 | 1.0 (ref) | 1.0 (ref) |
| Low-Moderate LUTS: 8–14 | 49 | 1.08 (0.80–1.46) | 1.07 (0.79–1.44) | 133 | 1.33 (1.11–1.60) | 1.31 (1.09–1.57) |
| High-Moderate LUTS: 15–19 | 18 | 2.12 (1.34–3.35) | 2.07 (1.31–3.28) | 25 | 1.26 (0.88–1.81) | 1.27 (0.89–1.83) |
| Severe LUTS: 20–35 | 8 | 2.22 (1.14–4.36) | 2.24 (1.13–4.41) | 15 | 1.53 (0.96–2.44) | 1.37 (0.89–2.13) |
| p trend | 0.004 | 0.004 | 0.0002 | 0.0006 | ||
| Surgery for BPH | 15 | 2.33 (1.42–3.83) | 2.22 (1.37–3.59) | 58 | 1.30 (1.01–1.67) | 1.25 (0.98–1.61) |
| Medications for BPH | 13 | 1.35 (0.78–2.34) | 1.22 (0.71–2.10) | 46 | 1.32 (1.00–1.75) | 1.24 (0.94–1.65) |
| p for interaction = 0.19 | ||||||
Adjusting for age in years (continuous)
Adjusting for age in years (continuous), body mass index (BMI kg/m2, continuous), lifetime cumulative cigarette smoking (never, current <15 pack-years, current ≥ 15 pack-years, current unknown pack-years, former <5 pack-years, former 5–9 pack-years, former ≥ 10 pack-years, former unknown pack-years, missing smoking status), physical activity (none/missing, quartiles of MET-hrs/week), race (African-American, Asian, Southern European, Scandinavian, other Caucasian, other), fruit and vegetable intake (quintiles), alcohol intake (none, <5g/day, 5-<15 g/day, 15-<30 g/day, 30-<50 g/day, ≥ 50 g/day), diabetes (ever/never), hypertension (ever/never), and cardiovascular disease (ever/never)
LUTS or surgery for BPH reported in 1994 or earlier, and incident ED newly reported 1995 or later (cohort 1)
LUTS or surgery for BPH, or medications for BPH reported in 1998 or earlier, and incident ED in the three months prior to the return of the 2000 questionnaire (cohort 2)
For the analysis of incident ED in 1995 or later, men categorized according to their maximum reported AUA Symptom Index score on 1992 or 1994 questionnaire. For the analysis of incident ED in the last three months, men categorized according to their maximum reported AUA Symptom Index score on 1992, 1994, or 1998 questionnaire.