Table 3.

ECASS II Exclusion Criteria

Age < 18 or > 80 years

Intracerebral hemorrhage

> 1/3 middle cerebral artery distribution hypoattenuation on CT

SAH

Unknown symptom onset time

Coma or stupor

Hemiplegia with fixed eye deviation

Minor stroke symptoms* or rapid symptom improvement before t-PA

SBP > 185 mm Hg or DBP > 110 mm Hg

Traumatic brain injury within 14 days

CNS surgery within 3 months

GI or urinary tract hemorrhage

IV or SQ heparin

Hereditary or acquired bleeding diathesis

Lactation or pregnancy

Contraception

50 mg/dL > glucose > 400 mg/dL

Participation in another drug trial within 3 months

ECASS = European Cooperative Acute Stroke Study; CT = computed tomography; SAH = subarachnoid hemorrhage; tPA = tissue plasminogen activator; SBP = systolic blood pressure; DBP = diastolic blood pressure; CNS = central nervous system; GI = gastrointestinal; IV = intravenous; SQ = subcutaneous.

^*Scandinavian Stroke Scale > 50.