Table 2.
DAVID FACs identify metabolism and energy generation as pathways having circannual regulation in 13-lined ground squirrels
| Cluster | Enrichment Score | Annotations, n | Genes, n |
|---|---|---|---|
| Mitochondrion | 20.24 | 4 | 23 |
| Mitochondrial lumen | 15.28 | 3 | 19 |
| Organelle lumen | 7.82 | 3 | 24 |
| Tricarboxylic acid cycle | 7.59 | 5 | 6 |
| Glucose catabolic process | 4.87 | 11 | 6 |
| Lipoic acid binding | 4.65 | 7 | 4 |
| Oxidoreductase activity | 4.41 | 3 | 4 |
| Mitochondrial alpha-ketoglutarate dehydrogenase complex | 3.78 | 4 | 3 |
| Lipid metabolism | 3.05 | 16 | 5 |
| Mitochondrial membrane | 2.56 | 7 | 8 |
| NAD or NADH binding | 2.27 | 4 | 4 |
| Oxidative phosphorylation | 1.76 | 10 | 4 |
| Cytoplasmic vesicle | 1.69 | 4 | 7 |
| Macromolecular complex assembly | 1.53 | 4 | 7 |
| ATP binding | 1.59 | 6 | 12 |
| Chaperone | 1.44 | 3 | 4 |
| Response to heat | 1.42 | 3 | 3 |
Functional Annotation Clusters (FACs) with an enrichment score >1.3 are listed for the 50 unique proteins found significant by ANOVA (q < 0.05) and identified by mass spectrometry. For each enriched FAC, the cluster term that provided the best biological meaning is presented.