Table 2.
Microarray and qPCR expression fold change of prioritized cis-eQTLs with validated differential expression in parental strains
| Affymetrix Probe-set ID | Gene Symbol | Gene Name | Tissue | Microarray Fold Change | Microarray P Value | qPCR Fold Change | qPCR P Value | Corrected P Value |
|---|---|---|---|---|---|---|---|---|
| 1370148_at | Hp | haptoglobin | adrenal | 6.45 | 2.0E-02 | 7.89 | <1.0E-04 | <5.0E-03 |
| 1370065_at | Hpx | hemopexin | adrenal | 4.64 | 1.0E-03 | 6.72 | <1.0E-04 | <5.0E-03 |
| 1372923_at | Pex11b | peroxisomal biogenesis factor 11 beta | adrenal | 2.69 | 1.0E-02 | 1.68 | <1.0E-04 | <5.0E-03 |
| 1368304_at | Fmo3 | flavin containing monooxygenase 3 | adrenal | 2.47 | 9.0E-04 | 2.51 | <1.0E-04 | <5.0E-03 |
| 1388617_at | Bphl | biphenyl hydrolase like | adrenal | 2.23 | 6.0E-03 | 2.96 | <1.0E-04 | <5.0E-03 |
| 1376249_at | Fuco2 | fucosidase 2 | adrenal | 1.72 | 1.0E-02 | 4.42 | <1.0E-04 | <5.0E-03 |
| 1374921_at | Rtel1 | regulator of telomere elongation helicase 1 | adrenal | 1.57 | 7.0E-04 | 2.49 | <1.0E-04 | <5.0E-03 |
| 1373864_at | Map4k4 | mitogen activated protein kinase kinase kinase kinase 4 | adrenal | 0.60 | 7.0E-05 | 0.64 | <1.0E-04 | <5.0E-03 |
| 1398908_at | Stoml2 | stomatin like 2 | adrenal | 0.55 | 1.0E-02 | 0.66 | <1.0E-04 | <5.0E-03 |
| 1388366_at | Mrpl4 | mitochondrial ribosomal protein L4 | adrenal | 0.51 | 6.0E-03 | 0.37 | <1.0E-04 | <5.0E-03 |
| 1389572_at | Me3 | malic enzyme 3 | adrenal | 0.49 | 3.0E-04 | 0.46 | 1.0E-04 | <5.0E-03 |
| 1367986_at | Ptgfrn | prostaglandin F2 receptor negative regulator precursor | adrenal | 0.25 | 9.0E-06 | 0.26 | <1.0E-04 | <5.0E-03 |
| 1370881_at | Tst | thiosulfate sulfurtransferase | adrenal | 0.22 | 4.0E-02 | 0.27 | <1.0E-04 | <5.0E-03 |
| 1387808_at | Slc7a7 | solute carrier family 7 member 7 | fat | 3.30 | 5.0E-03 | 5.38 | <1.0E-04 | <5.0E-03 |
| 1388617_at | Bphl | biphenyl hydrolase like | fat | 1.62 | 2.0E-02 | 2.07 | <1.0E-04 | <5.0E-03 |
| 1388912_at | Rexo4 | RNA exonuclease 4 homolog | fat | 0.59 | 5.0E-04 | 0.42 | <1.0E-04 | <5.0E-03 |
| 1368891_at | Gnpat | glyceronephosphate O-acyltransferase | fat | 0.56 | 1.0E-02 | 0.77 | 1.3E-03 | 0.03 |
| 1388366_at | Mrpl4 | mitochondrial ribosomal protein L4 | fat | 0.49 | 3.0E-04 | 0.37 | <1.0E-04 | <5.0E-03 |
| 1369171_at | Mst1 | macrophage stimulating 1 | fat | 0.21 | 6.0E-04 | 0.15 | <1.0E-04 | <5.0E-03 |
| 1377452_at | Clec3b | C-type lectin domain family 3, member b | fat | 0.02 | 2.0E-03 | 0.29 | <1.0E-04 | <5.0E-03 |
| 1371137_at | Acox2 | acyl coenzyme A oxidase 2, branched chain | kidney | 9.80 | 4.0E-03 | 11.08 | <1.0E-04 | <5.0E-03 |
| 1383303_at | Acsm3 | acyl-CoA synthetase medium chain family member 3 | kidney | 9.00 | 3.0E-04 | 10.39 | <1.0E-04 | <5.0E-03 |
| 1370401_at | Ly6b | lymphocyte antigen 6 complex, locus B | kidney | 5.53 | 1.0E-03 | 3.86 | <1.0E-04 | <5.0E-03 |
| 1387314_at | Sult1b1 | sulfotransferase family cytosolic, 1B, member 1 | kidney | 4.60 | 9.0E-03 | 2.28 | <1.0E-04 | <5.0E-03 |
| 1388366_at | Mrpl4 | mitochondrial ribosomal protein L4 | kidney | 0.52 | 2.0E-03 | 0.46 | <1.0E-04 | <5.0E-03 |
| 1367917_at | Cyp2d2 | cytochrome P450, family 2, subfamily d, polypeptide 2 | kidney | 0.45 | 3.0E-04 | 0.44 | <1.0E-04 | <5.0E-03 |
| 1386985_at | Gstm | glutathione S-transferase, mu | kidney | 0.42 | 7.0E-06 | 0.24 | <1.0E-04 | <5.0E-03 |
| 1368292_at | Dnm1 | dynamin 1 | kidney | 0.37 | 7.0E-06 | 0.20 | <1.0E-04 | <5.0E-03 |
| 1387819_at | Cela1 | chymotrypsin-like elastase family, member 1 | kidney | 0.28 | 9.0E-05 | 0.18 | <1.0E-04 | <5.0E-03 |
| 1370269_at | Cyp1a1 | cytochrome P450, family 1, subfamily a, polypeptide 1 | kidney | 0.25 | 3.0E-05 | 0.17 | 2.5E-04 | 6.6E-03 |
| 1393902_at | Akr1c1 | aldo-ketoreductase family 1, member C1 | kidney | 0.24 | 3.0E-08 | 0.23 | <1.0E-04 | <5.0E-03 |
| 1370176_at | Trak2 | trafficking protein, kinesin binding 2 | muscle | 2.02 | 4.0E-03 | 1.28 | <1.0E-04 | <5.0E-03 |
| 1385201_at | Tmem182 | transmembrane protein 182 | muscle | 1.57 | 1.0E-02 | 1.85 | <1.0E-04 | <5.0E-03 |
| 1374467_at | Trap1 | TNF receptor associated protein 1 | muscle | 1.56 | 5.0E-03 | 2.35 | <1.0E-04 | <5.0E-03 |
| 1388508_at | Fam32a | family with sequence similarity 32, member a | muscle | 0.58 | 9.0E-03 | 0.65 | <1.0E-04 | <5.0E-03 |
| 1388366_at | Mrpl4 | mitochondrial ribosomal protein L4 | muscle | 0.52 | 2.0E-05 | 0.55 | <1.0E-04 | <5.0E-03 |
Microarray fold change is the mean spontaneously hypertensive rat (SHR) parental strain expression/mean Brown Norway (BN) parental strain expression by microarray. qPCR fold change is the mean SHR parental strain expression/mean BN parental strain expression by qPCR. Corrected P value is the Bonferroni corrected P value.