Table 3.
Quantitative trait transcript analysis showing the highest correlating trait in the tissue in which the expression trait was observed for each cis-eQTL (n = 22) whose expression correlates highly (P ≤ 0.01) with physiological, metabolic, or cardiovascular traits
| Gene | Chromosome | Tissue in Which Correlation is Found | Trait | Pearson Correlation Coefficient | P Value |
|---|---|---|---|---|---|
| Acox2 | 15 | kidney | night time telemetry DBP after captopril | 0.71 | <1.0E-04 |
| Acsm3 | 1 | kidney | weight of the fat pad relative to body weight | 0.53 | 6.0E-03 |
| Akr1c1 | 17 | kidney | LDL phospholipids in rats at the age of 11 wk in rats fed a high fat, high cholesterol diet for 4 wk | 0.65 | <1.0E-04 |
| Cela1 | 7 | kidney | basal glucose uptake by adipocytes | 0.50 | 1.0E-02 |
| Cyp1a1 | 8 | kidney | HDL3 cholesterol in rats at the age of 7 wk in rats when fed a normal diet | 0.60 | <1.0E-04 |
| Cyp2d2 | 7 | kidney | HDL3 cholesterol in rats at the age of 7 wk in rats when fed a normal diet | 0.57 | 1.0E-03 |
| Dnm1 | 3 | kidney | adrenal dopamine beta hydroxylase (pmol/h/mg protein) | 0.54 | 7.0E-04 |
| Fmo3 | 13 | fat | serum ACTH (corticotropin) levels after 20 min of immobilization stress | 0.54 | 1.0E-02 |
| Fuco2 | 1 | fat | liver cholesterol concentrations in rats fed a high fat, high cholesterol diet from the age of 7–11 wk | 0.65 | 2.0E-04 |
| Gnpat | 19 | skeletal muscle | daytime telemetry SBP after captopril | 0.68 | <1.0E-04 |
| Hp | 19 | adrenal | kidney cortex conjugated dienes (nM/mg protein) | 0.69 | <1.0E-04 |
| Hpx | 1 | adrenal | serum dopamine levels | 0.48 | 8.0E-03 |
| Ly6b | 7 | kidney | lipolysis glycerol levels (mmol/g tissue/2 h) | 0.57 | 9.0E-03 |
| Map4k4 | 9 | adrenal | serum corticosterone levels after 140 min of immobilization stress | 0.71 | 4.0E-04 |
| Me3 | 1 | adrenal | mean arterial pressure (mmHg) | 0.57 | 1.0E-03 |
| Pex11b | 2 | adrenal | blood sugar [120 min during oral glucose tolerance test (fructose diet) (mmol] | 0.56 | 2.0E-03 |
| Rexo4 | 3 | adrenal | hematocrit (proportion of blood volume occupied by red blood cells) at the age of 30 days | 0.83 | 8.0E-03 |
| Rtel1 | 3 | adrenal | LDL cholesterol in rats at the age of 7 wk in rats fed a normal diet | 0.57 | 2.0E-03 |
| Slc7a7 | 15 | fat | serum ACTH (corticotropin) levels after 20 min of immobilization stress | 0.54 | 1.0E-02 |
| Trak2 | 9 | skeletal muscle | insulin stimulated glucose uptake by adipocytes | 0.58 | 3.0E-03 |
| Trap1 | 10 | skeletal muscle | serum corticosterone levels after 80 min of immobilization stress | 0.67 | 1.0E-03 |
| Tst | 7 | adrenal | weight of the fat pad relative to body weight | 0.58 | 2.0E-03 |
A full list of trait names is given in Supplementary Table S2. Full details of all traits that were significantly correlated with a cis-eQTL are given in Supplementary Table S5.