Table 4.
Distribution of SHR sequence variants in c3-eQTL genes
| Flanking Region |
Transcript |
Intronic |
||||||
|---|---|---|---|---|---|---|---|---|
| Gene | Upstreama | Downstreama | 5′-UTRb | Splice Sitec | Silentd | Nonsynonymouse | 3′-UTRf | Intron |
| Tst | 30 | 19 | 0 | 0 | 2 | 0 | 0 | 30 |
| Hp | 32 | 2 | 0 | 0 | 0 | 0 | 0 | 1 |
| Me3 | 3 | 30 | 0 | 0 | 1 | 0 | 0 | 142 |
| Acox2 | 23 | 9 | 0 | 1 | 5 | 2 | 0 | 84 |
| Ly6b | 21 | 9 | 0 | 0 | 0 | 0 | 1 | 19 |
| Cyp1a1 | 10 | 15 | 0 | 0 | 1 | 0 | 1 | 9 |
| Akr1c1 | 8 | 15 | 0 | 0 | 0 | 1 | 3 | 37 |
| Pex11b | 8 | 10 | 0 | 2 | 0 | 2 | 2 | 27 |
| Cela1 | 15 | 3 | 0 | 0 | 2 | 2 | 0 | 47 |
| Trak2 | 7 | 3 | 1 | 1 | 1 | 0 | 1 | 111 |
| Hpx | 4 | 5 | 1 | 0 | 0 | 0 | 1 | 17 |
| Cyp2d2 | 3 | 2 | 0 | 0 | 0 | 0 | 0 | 2 |
a
Region located within 5 kb upstream of the transcription initiation site or 5 kb downstream of transcript end.
b
Number of sequence variants in the 5′-untranslated region (UTR).
c
Number of sequence variants occurring in splice sites, i.e., the region located 1-3 bp into exon or 1-8 bp into an intron.
d
Number of sequence variants located in coding region that do not affect amino acid sequence.
e
Number of sequence variants located in coding region that do affect amino acid sequence.
f
Number of sequence variants in the 3′-UTR. c3-eQTL, colocalizing, correlated cis-eQTL.