Table 2.
Analysis of DEspR (rs6535847) variant based on blood pressure as a quantitative trait
| Genotypes | n | Mean SBP ± SE, mmHg | Δ SBP | P | Mean DBP ± SE, mmHg | Δ DBP | P |
|---|---|---|---|---|---|---|---|
| Male + female cohort | |||||||
| C/C | 305 | 158.5 ± 2.2 | 101.2 ± 1.5 | ||||
| [C/T + T/T] | 337 | 154.8 ± 1.8 | 3.7 | 0.076 | 96.7 ± 1.2 | 4.5 | 0.021 |
| Female cohort | |||||||
| C/C | 145 | 154.1 ± 3.2 | 95.6 ± 1.9 | ||||
| [C/T + T/T] | 158 | 158.6 ± 2.8 | −4.5 | 0.324 | 96.3 ± 1.8 | −0.7 | 0.726 |
| Male cohort | |||||||
| C/C | 160 | 162.5 ± 2.9 | 106.3 ± 2.7 | ||||
| [C/T + T/T] | 179 | 151.5 ± 2.3 | 11.0 | <10−15 | 97.0 ± 2.2 | 9.3 | <10−15 |
Blood pressures were adjusted for age, body mass index, and case/control status.
n, Number of individuals; SBP, systolic blood pressure; DBP, diastolic blood pressure; Δ SBP, difference in systolic blood pressure; Δ DBP, difference in diastolic blood pressure; P, Mann-Whitney rank sum test P values.