Fig. 1.

Differential gene expression in Prop1 and Pit1 mutants. A: heat maps display differentially expressed genes with a significance of P < 0.05 and a fold change of at least 2. Intensity of expression is represented by a color scale where red has the lowest expression and green has the highest expression. Comparison of Prop1^df/df with Pit1^dw/dw reveals 524 genes with altered expression with a fold change of at least 2. The 2 wild-type stocks (Prop1^+/+ and Pit1^+/+) differ by 418 genes. Sixty-eight genes differ between Prop1^df/df and Prop1^+/+ 68 genes, and 53 differed between Pit1^+/+ and Pit1^dw/dw. B: a Venn diagram illustrates the total number of genes with significantly different expression in Prop1 mutants relative to wild type (left circle) and Pit1 mutants relative to wild type (right circle) out of 6,823 surveyed probe sets. 46 genes exhibited similar a degree of differential expression in both Prop1 and Pit1 dwarfs relative to their wild-type controls (intersection of the 2 circles).