Collagen Metabolism |
Mmp2 |
matrix metalloproteinase 2 |
3.1E-06 |
9.0E-14 |
1.5 |
1.1 |
1.4 |
2.6 |
4.7 |
6.2 |
Mmp14 |
matrix metallopeptidase 14 |
9.3E-04 |
6.7E-13 |
1.2 |
1.0 |
1.6 |
3.1 |
7.3 |
7.9 |
Mmp3 |
matrix metalloproteinase 3 |
2.4E-02 |
1.4E-10 |
0.6 |
1.3 |
3.7 |
2.5 |
18.0 |
6.1 |
Mmp11 |
matrix metalloproteinase 11 |
3.0E-02 |
1.3E-06 |
2.2 |
1.3 |
1.1 |
2.8 |
2.0 |
2.1 |
Adamts2 |
a disintegrin-like and metalloprotease type 2 |
3.9E-02 |
2.5E-09 |
1.1 |
1.0 |
1.3 |
1.7 |
2.4 |
2.0 |
Mmp13 |
matrix metalloproteinase 13 |
4.4E-01 |
8.0E-14 |
0.6 |
1.8 |
2.5 |
8.4 |
1217 |
406.6 |
Caspase Activity |
Casp8 |
caspase 8 |
5.4E-02 |
6.3E-10 |
0.9 |
1.1 |
1.5 |
2.9 |
1.7 |
1.7 |
Casp6 |
caspase 6 |
2.3E-02 |
2.0E-05 |
1.0 |
1.0 |
1.4 |
2.6 |
1.8 |
1.4 |
Casp3 |
caspase 3 |
1.5E-02 |
3.0E-10 |
1.0 |
1.4 |
1.2 |
3.3 |
2.1 |
1.8 |
Casp11 |
caspase 11 |
6.3E-01 |
1.1E-08 |
0.6 |
1.2 |
1.5 |
2.6 |
2.3 |
1.9 |
Casp1 |
caspase 1 |
1.1E-01 |
1.4E-05 |
0.9 |
1.2 |
1.4 |
7.6 |
2.2 |
1.9 |
Apaf1 |
apoptotic protease activating factor 1 |
3.8E-01 |
1.7E-09 |
0.9 |
1.0 |
1.2 |
2.5 |
1.8 |
1.3 |
Mitochodrial Function |
Abcb6 |
ATP-binding cassette, sub-family B, 6 |
1.2E-01 |
2.8E-07 |
1.0 |
0.9 |
0.9 |
1.0 |
0.6 |
0.7 |
Acaa2 |
mitochondrial 3-oxoacyl-Coenzyme A thiolase |
8.4E-08 |
1.4E-06 |
1.0 |
0.6 |
0.6 |
0.6 |
0.6 |
0.6 |
Acas2l |
acetyl-Coenzyme A synthetase 2 like |
6.0E-07 |
1.7E-01 |
0.6 |
0.6 |
0.8 |
1.1 |
1.2 |
1.1 |
Bckdhb |
branched chain ketoacid dehydrogenase E1 |
6.6E-01 |
1.6E-06 |
1.1 |
1.2 |
0.8 |
0.6 |
0.9 |
0.8 |
Cox6a1 |
cytochrome c oxidase, subunit VI a1 |
1.6E-01 |
9.6E-10 |
0.8 |
1.0 |
1.1 |
2.1 |
1.5 |
1.6 |
Dlat |
dihydrolipoamide S-acetyltransferase |
4.9E-08 |
7.8E-12 |
1.0 |
0.7 |
0.8 |
0.5 |
0.6 |
0.6 |
Mrpl17 |
mitochondrial ribosomal L17 |
2.3E-09 |
2.6E-04 |
0.6 |
0.8 |
0.6 |
0.7 |
0.7 |
0.7 |
Mrpl51 |
mitochondrial ribosomal L51 |
1.9E-12 |
4.0E-07 |
0.6 |
0.7 |
0.7 |
0.5 |
0.6 |
0.8 |
Ndufab1 |
NADH dehydrogenase |
1.1E-05 |
3.2E-06 |
0.7 |
0.6 |
0.8 |
0.6 |
0.5 |
0.7 |
Ndufs4 |
NADH dehydrogenase 4 |
1.6E-01 |
5.5E-07 |
1.3 |
0.8 |
0.8 |
0.6 |
0.6 |
0.7 |
Timm22 |
translocase of inner mitochondrial membrane 2 |
2.3E-03 |
9.5E-05 |
0.9 |
0.8 |
0.7 |
0.6 |
0.6 |
0.8 |
Timm8a |
translocase of inner mitochondrial membrane 8 |
3.1E-10 |
2.2E-01 |
0.6 |
0.8 |
0.9 |
1.0 |
0.9 |
0.9 |
Muscle Biogenesis |
Acta2 |
actin, alpha 2 |
2.6E-05 |
6.6E-02 |
1.4 |
1.5 |
1.2 |
0.6 |
0.9 |
1.0 |
Actc1 |
actin, alpha, cardiac |
5.9E-07 |
1.8E-08 |
1.1 |
0.2 |
0.5 |
0.4 |
0.2 |
0.7 |
Actg1 |
actin, gamma, cytoplasmic 1 |
3.6E-05 |
1.0E-11 |
0.6 |
0.9 |
1.1 |
2.2 |
1.5 |
1.8 |
Dmd |
dystrophin, muscular dystrophy |
7.4E-05 |
6.7E-05 |
2.0 |
1.3 |
1.3 |
0.4 |
0.5 |
0.8 |
Igf1 |
Insulin-like growth factor 1 |
9.7E-01 |
7.8E-08 |
0.8 |
1.0 |
1.3 |
1.7 |
2.3 |
2.3 |
Mef2c |
myocyte enhancer factor 2C |
5.1E-05 |
6.3E-02 |
1.5 |
1.4 |
1.4 |
0.5 |
0.8 |
1.1 |
Mybph |
myosin binding protein H |
5.4E-06 |
1.7E-02 |
0.3 |
0.4 |
1.0 |
0.6 |
1.5 |
5.2 |
Myh1 |
myosin, heavy polypeptide 1 |
2.1E-01 |
4.2E-01 |
1.0 |
1.0 |
0.9 |
0.9 |
0.9 |
1.1 |
Myh2 |
myosin, heavy polypeptide 2 |
2.4E-02 |
1.2E-02 |
1.0 |
0.9 |
1.0 |
0.7 |
0.8 |
1.0 |
Myh3 |
myosin, heavy polypeptide 3 |
3.3E-07 |
4.2E-01 |
0.5 |
0.3 |
0.5 |
0.9 |
1.2 |
1.3 |
Myh4 |
myosin, heavy polypeptide 4 |
1.9E-01 |
2.6E-02 |
1.0 |
1.0 |
1.0 |
0.7 |
0.8 |
0.9 |
Myh7 |
myosin, heavy polypeptide 7 |
2.1E-03 |
1.1E-02 |
1.1 |
0.8 |
0.6 |
0.2 |
0.6 |
0.9 |
Myl2 |
myosin, light polypeptide 2, |
9.9E-12 |
4.0E-10 |
0.8 |
0.5 |
0.6 |
0.1 |
0.2 |
0.4 |
Myl3 |
myosin, light polypeptide 3 |
7.8E-06 |
1.3E-09 |
1.0 |
0.6 |
0.7 |
0.3 |
0.2 |
0.4 |
Myog |
myogenin |
4.7E-01 |
4.0E-11 |
0.9 |
1.0 |
1.4 |
3.6 |
1.7 |
1.8 |
Myom2 |
myomesin 2 |
3.1E-03 |
5.6E-05 |
1.2 |
1.0 |
1.0 |
0.6 |
0.7 |
1.1 |
Tnnc1 |
troponin C, cardiac/slow skeletal |
3.4E-03 |
2.3E-02 |
1.1 |
0.7 |
0.7 |
0.5 |
0.6 |
0.7 |
Tnnc2 |
troponin C2, fast |
2.3E-01 |
3.2E-01 |
0.9 |
1.0 |
1.0 |
1.0 |
1.0 |
1.0 |
Tnni1 |
troponin I, skeletal, slow 1 |
1.3E-08 |
3.8E-01 |
0.8 |
0.5 |
0.5 |
0.6 |
0.8 |
1.0 |
Tnni2 |
troponin I, skeletal, fast 2 |
3.6E-02 |
4.6E-05 |
1.1 |
0.9 |
0.6 |
0.5 |
0.6 |
0.4 |
Tnnt1 |
troponin T1, skeletal, slow |
1.4E-03 |
9.7E-01 |
1.1 |
0.7 |
0.6 |
0.6 |
1.1 |
1.6 |
Tnnt3 |
troponin T3, skeletal, fast |
3.1E-01 |
3.1E-01 |
1.1 |
1.1 |
0.9 |
1.0 |
1.0 |
0.9 |
Tpm1 |
tropomyosin 1, alpha |
1.6E-02 |
2.1E-06 |
0.7 |
0.9 |
1.1 |
1.4 |
1.5 |
1.7 |
Tpm2 |
tropomyosin 2, beta |
1.6E-08 |
1.5E-12 |
1.0 |
0.8 |
0.8 |
0.4 |
0.4 |
0.8 |
Tpm3 |
tropomyosin 3, gamma |
5.7E-01 |
2.8E-07 |
0.7 |
1.1 |
1.2 |
2.5 |
1.6 |
1.6 |
Tpm4 |
tropomyosin 4 |
3.5E-05 |
2.5E-09 |
0.5 |
0.8 |
1.2 |
2.8 |
2.3 |
1.9 |
Lysosomal Function |
Apg4d |
APG4 (ATG4) autophagy-related homolog D |
8.6E-10 |
9.5E-08 |
0.7 |
0.8 |
0.7 |
0.6 |
0.7 |
0.7 |
Ctsc |
cathepsin C |
2.5E-02 |
1.2E-14 |
1.0 |
1.1 |
1.5 |
4.2 |
2.0 |
1.4 |
Lamp2 |
lysosomal membrane glycoprotein 2 |
3.8E-02 |
5.8E-10 |
1.2 |
1.1 |
1.0 |
2.3 |
2.4 |
2.3 |
Lip1 |
lysosomal acid lipase 1 |
5.4E-01 |
1.7E-13 |
0.9 |
1.0 |
1.3 |
3.6 |
2.2 |
1.9 |
Naglu |
alpha-N-acetylglucosaminidase |
3.6E-06 |
1.2E-12 |
1.5 |
1.1 |
1.1 |
1.9 |
1.7 |
1.8 |
Npc2 |
Niemann Pick type C2 |
3.7E-02 |
4.9E-14 |
1.0 |
1.0 |
1.2 |
2.9 |
1.9 |
1.6 |
Ctsb |
cathepsin B |
7.1E-01 |
8.8E-16 |
0.9 |
1.0 |
1.1 |
3.3 |
1.7 |
1.4 |
Ctsc |
cathepsin C |
2.5E-02 |
1.2E-14 |
1.0 |
1.1 |
1.5 |
4.2 |
2.0 |
1.4 |
Ctse |
cathepsin E |
9.9E-01 |
1.7E-03 |
0.9 |
1.0 |
1.2 |
0.6 |
0.9 |
0.5 |
Ctsh |
cathepsin H |
7.2E-01 |
7.2E-14 |
0.7 |
1.0 |
1.4 |
6.6 |
3.0 |
2.2 |
Ctsk |
cathepsin K |
1.2E-04 |
1.9E-14 |
1.6 |
1.1 |
1.5 |
2.7 |
8.3 |
8.4 |
Ctss |
cathepsin S |
7.5E-03 |
1.0E-16 |
0.8 |
1.4 |
1.9 |
15.8 |
4.3 |
2.6 |
Ctsz |
cathepsin Z |
4.1E-01 |
3.8E-12 |
0.9 |
1.0 |
1.2 |
3.0 |
2.0 |
1.5 |
Gla |
galactosidase, alpha |
4.5E-01 |
1.2E-02 |
1.0 |
1.0 |
1.2 |
3.4 |
1.2 |
1.1 |
Glb1 |
galactosidase, beta 1 |
8.4E-03 |
3.1E-07 |
0.8 |
0.9 |
0.8 |
2.9 |
1.7 |
1.8 |
Gusb |
glucuronidase, beta |
7.6E-02 |
4.4E-12 |
0.7 |
0.9 |
1.1 |
3.7 |
1.6 |
1.4 |
Hexa |
hexosaminidase A |
8.1E-03 |
6.5E-15 |
0.8 |
1.0 |
1.0 |
2.5 |
1.8 |
1.5 |
Hexb |
hexosaminidase B |
4.4E-01 |
4.9E-12 |
1.1 |
1.1 |
1.0 |
7.0 |
2.9 |
2.5 |
Lip1 |
lysosomal acid lipase 1 |
5.4E-01 |
1.7E-13 |
0.9 |
1.0 |
1.3 |
3.6 |
2.2 |
1.9 |
Man1a |
mannosidase 1, alpha |
4.2E-01 |
4.0E-09 |
0.9 |
0.9 |
1.3 |
2.3 |
2.1 |
1.8 |
Psap |
prosaposin |
3.6E-01 |
1.0E-07 |
1.0 |
1.0 |
1.0 |
1.6 |
1.1 |
1.0 |
Proteasome Function |
Psmc1 |
protease 26S subunit, ATPase 1 |
1.7E-14 |
4.2E-01 |
1.6 |
1.3 |
1.1 |
1.1 |
1.0 |
1.0 |
Psmc4 |
proteasome 26S subunit, ATPase, 4 |
4.8E-09 |
4.7E-01 |
1.6 |
1.2 |
1.0 |
1.2 |
0.9 |
1.0 |
Psmd2 |
proteasome 26S subunit, non-ATPase, 2 |
2.5E-13 |
2.2E-02 |
1.3 |
1.6 |
1.1 |
1.3 |
1.0 |
1.0 |
Ubc |
ubiquitin C |
2.0E-06 |
5.9E-04 |
2.7 |
1.3 |
1.0 |
0.7 |
0.7 |
0.7 |
Fbxo32 |
F-box only protein 32 |
6.38E-09 |
0.0819765 |
2.7 |
1.9 |
1.3 |
1.5 |
1.3 |
0.8 |
Trim63 |
tripartite motif-containing 63 |
1.08E-05 |
0.1525747 |
1.9 |
1.1 |
1.0 |
1.6 |
1.0 |
0.9 |