Table 3.

Pathways regulated during muscle atrophy identified by Sigpathway analysis

	Casting			Tenotomy
Gene Sets	2 Days	7 Days	14 Days	2 Days	7 Days	14 Days
CANCER MODULE_46 INFLAMMATION	−6.8	3.3	9.8	19.1	15.1	11.0
EXTRACELLULAR_MATRIX	−6.2	−5.5	2.4	7.4	12.0	14.4
MITOCHONDRION	−0.2	−8.2	−11.2	−11.7	−11.9	−12.4
HSA03050_PROTEASOME	10.3	11.9	3.9	4.9	0.5	−0.6
ELECTRON_TRANSPORT_CHAIN	−2.0	−7.7	−5.0	−7.9	−7.2	−5.7
HSA00190_OXIDATIVE_PHOSPHORYLATION	−0.9	−7.1	−5.9	−6.8	−5.5	−4.5
KREBS_TCA_CYCLE	0.3	−6.2	−5.3	−6.3	−5.8	−5.0
GLYCOLYSIS_AND_GLUCONEOGENESIS	−1.5	−5.8	−3.5	−3.7	−3.5	−2.8
HSA00020_CITRATE_CYCLE	0.6	−5.2	−5.7	−5.4	−4.6	−4.2
LYSOSOME	1.3	0.7	0.9	5.1	3.2	2.8