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. Author manuscript; available in PMC: 2011 Nov 16.
Published in final edited form as: J Am Chem Soc. 2006 Dec 27;128(51):16764–16770. doi: 10.1021/ja057035p

Figure 1.

Figure 1

Hammerhead ribozyme (HHRz) construct used in this study. Nucleotides in red form the conserved core, and the circled G10.1 nucleotide is the site of 2′-deoxyguanosine modification (dG10.1) and specific 15N labeling. Arrow indicates the cleavage site. In samples used for spectroscopy, a 2′methoxy substitution was placed at C17 in the substrate strand to prevent cleavage.