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. 2011 Sep 19;118(20):5565–5572. doi: 10.1182/blood-2010-12-327437

Figure 2.

Figure 2

Persistence of BCR-ABL+ cells in primitive progenitor/stem cells in CML patients in CCR with imatinib mesylate treatment for 5 years. (A) Experimental procedures for isolating CD34+CD38+ and CD34+CD38 cells by flow cytometry sorting followed by Q-PCR for BCR-ABL and BCR are shown. (B) The cumulative results for Q-PCR analysis for BCR-ABL levels in MNC, CD34+CD38+, and CD34+CD38 cells in CML patients after 1 to 5 years of imatinib mesylate treatment are shown using box and whisker (Tukey) plots. Significance values comparing MNC and CD34+CD38 cells are *.05 > P < .1, **P < .01, ***P < .001; comparing CD34+CD38+ and CD34+CD38 cells are ^.05 > P < .1, ^P < .05.

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